3-Chlorosulfonyl-pyrrolidine-1-carboxylic acid tert-butyl ester - Names and Identifiers
3-Chlorosulfonyl-pyrrolidine-1-carboxylic acid tert-butyl ester - Physico-chemical Properties
Molecular Formula | C9H16ClNO4S
|
Molar Mass | 269.75 |
Density | 1.34 |
Boling Point | 353.5±31.0 °C(Predicted) |
pKa | -4.59±0.40(Predicted) |
Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
3-Chlorosulfonyl-pyrrolidine-1-carboxylic acid tert-butyl ester - Introduction
tert-butyl 3-(chlorosulfonyl)pyrrolidine-1-carboxylate is an organic compound with the chemical formula C10H17ClNO4S. The following is a brief description of its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline solid
-Molecular weight: 273.77g/mol
-Melting point: about 78-82 ℃
-Boiling point: about 340 ℃
-Solubility: Soluble in some organic solvents, such as ethanol, ether, etc.
-Chemical reaction: the compound can be esterified and aminated with other compounds
Use:
-Chemical synthesis: tert-butyl 3-(chlorosulfonyl)pyrrolidine-1-carboxylate can be used as an intermediate in organic synthesis for the synthesis of other organic compounds, such as drugs, fine chemicals, etc.
-Pharmaceutical field: The derivative of this compound may have certain biological activity and can be used for new drug research and development.
Method:
The preparation of tert-butyl 3-(chlorosulfonyl)pyrrolidine-1-carboxylate can be carried out by the following steps:
1. reacting tert-butyl pyrrolidine -1-carboxylate with di-tert-butyl phthalate to generate tert-butyl phthalate compound.
2. Under appropriate conditions, the target product can be obtained by reacting tert-butyl phthalate compound with thionyl chloride.
Safety Information:
- tert-butyl 3-(chlorosulfonyl)pyrrolidine-1-carboxylate may be toxic to humans and should be used with caution.
-In the process of operation, please wear protective gloves, protective glasses and other personal protective equipment.
-Avoid contact with skin, eyes and respiratory tract. If contact occurs, rinse immediately with plenty of water and seek medical assistance.
-Operate in a well-ventilated place and avoid dust, smoke, etc.
-It is strictly prohibited to mix with strong oxidants, acids and other substances to prevent dangerous reactions.
Please note that the information provided here is for reference only. Please refer to the official chemical literature and safety information for specific operations and uses.
Last Update:2024-04-09 15:18:00